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Shot 51 times in a movie theater, Aurora victim forges recovery

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A Sussex County woman wounded in the infamous "Batman" movie theater shooting has found post-traumatic stress disorder to be a tricky and unpredictable adversary. Reported by NJ.com 6 days ago.

The CEO of Morgan Stanley took a shot at the startups shaking up investing (MS)

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The CEO of Morgan Stanley took a shot at the startups shaking up investing (MS)· *Morgan Stanley has taken notable steps to expand its digital offerings in its wealth-management business.*
· *James Gorman, the firm's CEO, thinks pure robo platforms only appeal to a certain segment of the industry. **He also questions the cost savings associated with going robo. *

Roboadvisers claim they're going to dominate money management. Morgan Stanley CEO James Gorman isn't convinced.

The financial giant has announced a number of new digital offerings including a goals-based roboadviser option for the children of existing wealthy clients and for Morgan Stanley stock-plan participants. But Morgan Stanley's digital push is not an indicator that the firm's leadership thinks human advisers will become irrelevant.

Gorman said people have predicted the death of the human adviser before, but it never played out. 

"We actually saw this movie once before in 1999, when the direct plays came out, and the big fear was cannibalization," Gorman said."That would only have held true if people actually didn't value the financial advisors and advice that we're getting from those advisors, and it didn't play out that way."

Instead, Gorman said roboadvisers only appeal to a certain segment, robo-clients may move over to traditional players as they get older, and that traditional financial advisers are competitive on cost with roboadvisers when one considers all of the services they offer.

The wealth-management industry is made up of different "segments," according to Gorman. There are some folks who are well-served by digital advice, and others who are better served by human help. An individual who starts out with roboadvice might decide they want a traditional financial adviser as they grow older and wealthier.

"The reality is the marketplace has different segments based upon consumer preference, and I think the digital strategy makes all the sense in the world, but it's clearly a segment," Gorman said. "Whether they change their behavior as they become wealthy remains to be seen, but there's clearly a segment that wants to deal digitally just to serve as segment that wanted to deal through direct brokerage trading and so on."

To be sure, it stands to reason that the CEO of a firm with 15,777 advisers on the payroll would defend their value.

Still, when you stack up everything that a human adviser provides, according to Gorman, they're actually not that much more expensive for the client than a robo-platform. Here's Gorman:

If you look at the average basis points paid from the various robo-platforms, they range, in general, I think, from something like 20 to 40 basis points. If you look at the average basis points for full-service advisory, like ours, just divide our revenue into our assets, including everything, you get somewhere in the 70s, low-70 basis points.

The affordability of roboadvice platforms such as Betterment and Wealthfront is one reason investors have poured billions into their funds. Still, the two firms, which both manage less than $10 billion, are dwarfed by Morgan Stanley's giant wealth-management unit, which oversees $2.239 trillion.

Gorman said when you consider all of the services Morgan Stanley provides, such as the human advice, different investment products, research, and access to the hot equity deals, the price difference makes sense. 

"It's not clear to me that that is such an expensive gap," he said. 

A recent survey conducted by LinkedIn, the social networking site, shows that many financial professionals share Gorman's view. According to the survey, 43% of those surveyed from the wealth-management space think fintech is overhyped.

"Financial advisors/wealth managers lead the charge on thinking that there will always be demand for traditional financial services, whereas interest in fintech will rise and fall (43%, compared to 29% overall)," the report said. 

A big note on financial technology by Morgan Stanley, penned by a team of analysts led by Giulia Aurora Miotti, supports this notion that humans are safe in wealth-management. 

"The financial sector consumer often needs some sort of human contact, especially when abrupt market moves lead to unexpected losses," the analysts wrote.

As such, they expect firms that deploy a hybrid model of financial advice will be the best positioned for success in the wealth-management space moving forward. 

The so-called cyborg or hybrid model refers to a financial advice platform that pairs algorithm based financial planning with components of human interaction. It's essentially financial advice with a human face and robo insides.

Betterment, a firm many consider the poster child of roboadvice, provides a recent case study of the industry-wide shift towards hybrid financial advice. Earlier this year, the firm responded to the desire for human help by rolling out new hybrid services that pair human help with its computerized financial advice. 

*SEE ALSO: A big question mark is hanging over the hottest trend in investing*

Join the conversation about this story »

NOW WATCH: Tesla’s Model 3 is coming on Friday and it’s going to be the ‘largest consumer-product launch ever’ Reported by Business Insider 6 days ago.

Wettstein Agencies Initiates Denver Area Charity Event to Provide Support to Local Boy Struggling with Rare Form of Epilepsy

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The Wettstein Agencies, a full service provider of insurance management, financial planning, and related services that works with clients throughout central Colorado, is announcing the commencement of a regional charity event to benefit Dominik, a young local boy diagnosed with a rare form of epilepsy

Aurora, CO (PRWEB) July 21, 2017

The Wettstein Agencies, a central Colorado firm that provides insurance management assistance and financial consultations to communities in the greater Denver region, is announcing a charity drive to help raise support for Dominik, a young Denver native recently diagnosed with a very rare kind of epilepsy.

Until a few months ago, Dominik was a healthy and happy young boy. Suddenly, Dominik began having seizures, and was shortly thereafter diagnosed with Febrile Infection-Related Epilepsy Syndrome (FIRES). This is an exceedingly rare form of epilepsy that can potentially cause hundreds of seizures per day, and the root cause of the disease remains unclear.

“We understand how difficult this can be and want to bring relief to Dominik’s family,” states Mitchell Wettstein, owner and executive manager of the Wettstein Agencies. With the help of his firm, Wettstein is working to gather local support for Dominik in an effort to offset his family’s mounting medical costs.

To help provide this relief for Dominik and his family, the Wettstein Agencies team is working to raise awareness of his cause over social media and email channels that reach residents all across Colorado. The firm will also be producing a full page cover article sharing Dominik’s story, which is scheduled for publication in “Our Hometown,” a local webzine hosted by the Wettstein Agencies: http://wettsteinagencies.com/magazines/.

Nearly half a dozen charitable causes in the Denver area have received direct support from the Wettstein Agencies since late last year. As regional representatives of the “Agents of Change” charity empowerment program, Wettstein and his team plan to select and assist new Denver charities on a bimonthly basis.

The Wettstein Agencies team has made the following page available for those who would like to learn more about the Denver area charity event to provide relief to young Dominik and his family: http://wettsteinagencies.com/causes/relief-hope-dominik-family/. More information on additional charity initiatives hosted by the Wettstein Agencies can be found on the firm’s Community Causes listing: http://wettsteinagencies.com/community/.

About Wettstein Agencies    

As a Personal Finance Representative in Aurora, Colorado, agency owner Mitchell Wettstein knows many local families. His knowledge and understanding of the people in his community ensures that clients of Wettstein Agencies are provided with an outstanding level of service. Mitchell and his team look forward to helping families protect the things that are most important - family, home, car and more. Wettstein Agencies also offers clients a preparation strategy for achieving their financial goals. To contact an expert at Wettstein Agencies, visit http://wettsteinagencies.com/ or call (720) 263-6821 in Aurora or (303) 750-5959 in Castle Rock. Reported by PRWeb 5 days ago.

100 descendants and counting: The remarkable story of Pat Klingbeil

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Denver, Colo., Jul 21, 2017 / 10:30 am (CNA).- When most people hear about a stereotypical “large Catholic family,” they might picture a van that seats six or eight kids. Most wouldn’t think of having so many great-grandchildren that you’ve lost count.

But this is reality for Pat Klingbeil of Colorado.

Pat has nearly 50 great-grandchildren (an estimate she gave that was confirmed by one of her more mathematically talented daughters), having given birth to eight children and raised a total of 11.

“Parenting is a career,” she says, “and it has a lot of paybacks.”

One of the many signs and newspaper clippings hanging throughout her house bears the first half of that same message. Another, tucked amid jokes about Irish heritage and a morning prayer hanging above her coffee pot, depicts a mother surrounded by rambunctious children: “Lord, give me the strength to endure my many blessings!”

And her many blessings, along with the trials in which they have sometimes appeared, are something of which Pat often speaks in these conversations: “See how God works” and other such phrases are constant refrains of hers.

“It’s certainly been an adventure,” she said of her family. She paused before saying: “It’s what I always wanted to do, since I was old enough to know better. I always wanted to be a mom. So, to be blessed with a large family is just incredible.”

Dinnertimes at Pat’s are rarely low-profile events, as many nights out of a week the kitchen is packed with friends, former boarders, and most of all, her extensive family.

Pat was born in Aurora near Denver and just north of where she lives now, on St. Patrick’s Day in 1933 to an impoverished family.  

She discussed coming to a knowledge of God’s love, saying it was an awareness that slowly grew in her life, and came largely through her family: “having babies, giving birth, living the wonder of life, of having that experience.”

“I don’t think there was ever an ‘ah-ha!’ moment. I think it just began to develop in me. And as I lived, and as my children grew and all, I began to experience the presence, the presence of God.”

Pat speaks often of this presence of God. Far from being simply a nice Catholic slogan to her, it is something she always turns backs to, not only when talking about the joys of life, but also its sorrows.

“If there is a God, then you believe that he will not abandon you,” she says.

And the stories Pat tells reveal this clearly.

*A growing family*

Pat raised four of her grandchildren, after their parents (her stepdaughter and son-in-law) were murdered after a Fourth of July party in the early 1980s.

Neighbors and even families in Utah filed to take the kids, but only volunteered for one or two. However, the coroner promised Pat that she and her husband would be the ones to raise them.

“When all else fails, God’s still here, and I can still say, ‘Help me,’ and he does. And the best part of that is that he’s always allowed me to see that he’s helping me.”

And so the four grandchildren joined the family, and their grandparents became their mom and dad.

“When I became mamma to them, there was so much that need to be cared for and loved for, that I had to give myself to them,” Pat says.

Sadly, however, another trial waited which God would bear them through. A few years later, in 1988, her husband received a diagnosis with cancer. The eldest of the adopted grandchildren asked her new mom, “How many of my parents does God want to take away from me?”

Doctors gave him at most 18 months to live.

“And that’s what he took. He took 18 months,” says Pat.

He passed away in a hospital with Pat at his side.

“Everybody in the family, and close friends, all said, ‘What are you gonna do? What are you gonna do?’” Pat says.

“Well, you do whatever God sent you. And he takes care of it. If you ask him to take care of it, he takes care of it.”

Decades later, in 2004, Pat was invited by some friends to a Thanksgiving dinner. One of these felt it would be good for her to meet her boyfriend’s brother, Roger.

“We had dinner at their house on Thursday night, and when he walked me to my car, he said, ‘Well, will I see you again? Because I’m going back to Washington on Monday.’”

Pat offered for him to call her sometime.

He did so the next day, asking her to dinner.

After a meal where they both expressed distaste at the food, Roger walked Pat to her car.

“He said, ‘Can I kiss you goodnight?’ And I said, ‘Oh, I don’t think so.’ I don’t know where I was.”

The next day, Sunday, he came to Pat’s house, and the two simply chatted.

After he returned to Washington, the two stayed in touch over the phone. When Roger came back in town a couple weeks later, Pat invited him to her daughter and son-in-law’s house warming.

“Really and truly, I totally believe it, I’ve always told him: he fell in love with my family, and he wanted to be a part of my family.”

In 2005, Roger moved to Denver, and the next year they set the wedding date for August 13, the day after Pat’s grandson Matt married.

“We really did have a good time,” Pat says of their travelling the country and golfing together.

In 2010, the couple were staying a few nights in Estes Park on the way back from Washington. One day while they were there, Roger pointed out a swell on his stomach to Pat.

The two came home, saw a doctor the next morning, and received an MRI immediately.

It was her second time hearing the news of a spouse’s cancer diagnosis. This time, it was stage 4 liver and gallbladder cancer.

“It was harder because it was so hard for him,” Pat says. “He just cried, and he said, ‘I don’t want you to have to go through this again.’”

The doctors said he might live six months, but more likely around three weeks.

But just like her first husband, Roger lived the full time, passing away six months later on October 28.

“It’s a different experience this time,” Pat says.

She told me Roger’s story sitting in the living room by the backyard patio. When we had wrapped up our chat, she stood up and indicated a Divine Mercy image hanging above the wall. In front of this image, here in that room, she told me, she had prayed for Roger hours before he died in his hospice bed two rooms over.

*Difficult circumstances, unexpected blessings*

As a young mother while her first husband was serving overseas, Pat became pregnant after being raped. Her husband managed to secure a re-assignment in the States, and the young family moved to Eglin Air Force Base in Florida.

There, the family met a priest sympathetic to the situation, who found a couple willing to adopt the child. Pat delivered the child, who was then delivered to his new family.

“It doesn’t matter how that life is in you,” Pat says. “It matters how you nurture that life and allow it to grow in God’s image in likeness, and go on with your life in a proper way.” Pat has in years since given talks to young people which discuss, among other things, the challenges and beauty of adoption.

Around the year 1980, having been given his birth certificate by his adoptive mother, this son of Pat’s, named Joe, began searching for his birth mother. With the advent of the internet, he began using online genealogy tools and was able to hunt down her contact information.

Pat tells the story:

“Late morning, I answered the telephone, and this soft, quiet voice said, ‘This is not a business call, this is a personal call. My name is Joseph John Gongalski. I am calling looking for a Patricia Klingbeil. I was born at Eglin Air Force Base, Florida.”

Pat cut across him at this point: “And you weighed seven pounds, four ounces.”

As Pat tells it, Joe went “blubbery” at this point in the conversation.

They arranged for Joe, along with his wife and one of their sons, Matthew, to come to Pat’s birthday party on March 17, an annual event which draws family from across the country and friends from across the Denver area, packing the house.

Joe and his family arrived a couple of days early, and Pat, in her usual Irish mischief, had an idea.

“I decided that I would pull a trick on him.”

Grabbing Roger’s old cane, she hobbled out the door, bent halfway over, and made her way meekly across the lawn, surrounded by family armed with cameras.

“When we saw the car pull up, I went out across the lawn. He had gotten out of the car and was coming in between the cars on the driveway. And I’m coming across the grass with the cane and I’m bent way over, like a real old lady.”

From her feigned stoop, she could see Matthew over the cars.

“In that one glance, I could see his expression of, ‘Oh my God, look at her.’ It was just horror that was on his face!” she remembers, laughing.

“As Joe came out from between the cars, I threw the cane and ran to him.”

When Joe shows the video to church groups, audiences typically believe they’ve witnessed a miracle.

“I think that was the cream of it all,” says Pat, still laughing.

Joe and his wife Joanna now make regular visits to Pat from where they live in Michigan.

If you started from Pat’s name on a family tree and counted all the members extending below her, you’d count over 100 names. Among them would be kids, grandchildren raised as her kids, great-grandkids not yet born, a whole family rejoined after Joe’s search climaxed on her birthday one year: members lost, and members gained.

“See how God works,” as she says. Reported by CNA 4 days ago.

HIV discrimination claims against medical provider settled

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MILWAUKEE (AP) — The U.S. Department of Justice says it has settled discrimination claims from two HIV patients who said physicians at a Milwaukee-based medical provider refused to treat them because of their illness. The settlement announced Friday calls for Aurora Health Care Inc. to pay $30,000 to one patient, $15,000 to the other and […] Reported by Seattle Times 4 days ago.

Samtec Introduces 14 Gbps FireFlyTM FMC Development Kit

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Kits Provide Easy Connection Between FPGAs and Fiber Optics

New Albany, IN (PRWEB) July 24, 2017

Samtec, a privately held $662MM global manufacturer of a broad line of electronic interconnect solutions, proudly announces the release of the new 14 Gbps FireFly™ FMC Development Kit. This new solution offers an easy-to-use evaluation and development platform for Samtec’s FireFly™ optical engines.

The 14 Gbps FireFly™ FMC Module provides up to 140 Gbps full-duplex bandwidth over 10 channels from an FPGA to an industry-standard multi-mode fiber optic cable. Samtec’s 14 Gbps FireFly™ FMC Development Kit supports Data Center, High Performance Computing and FPGA-to-FPGA protocols including Ethernet, InfiniBandTM , Fibre Channel and Aurora.

FireFly™ optical engines make the electrical to optical conversion in the transmit path and the optical to electrical conversion in the receive path. They are based on proven 850 nm VCSEL array technology while featuring adjustable power levels to support cable lengths up to 100 m.

As a VITA 57.1-compliant FMC, Samtec’s 14 Gbps FireFly™ FMC Module can be used for optical data communication on any FMC-enabled FPGA development board supporting high-speed multi-gigabit transceivers. It can run system data or BERT testing from a single channel to all ten channels in parallel. Technical documentation and FPGA reference designs are available for quick start-up.

“Evaluating optical engine technology has high barriers of entry,” said Matt Burns, Product Marketing Manager at Samtec, Inc. “Samtec’s new 14 Gbps FireFly™ FMC Development Kit eases FireFly™ evaluation and development by leveraging the FMC interface common on most industry-standard FPGA development tools.”

For more information on the 14 Gbps FireFly™ FMC Development Kit, please download the Product Brief or visit http://www.samtec.com/14g-firefly-fmc.

About Samtec, Inc.
Founded in 1976, Samtec is a privately held, $662MM global manufacturer of a broad line of electronic interconnect solutions, including IC-to-Board and IC Packaging, High-Speed Board-to-Board, High-Speed Cables, Mid-Board and Panel Optics, Flexible Stacking, and Micro/Rugged components and cables. Samtec Technology Centers are dedicated to developing and advancing technologies, strategies and products to optimize both the performance and cost of a system from the bare die to an interface 100 meters away, and all interconnect points in between. With 33 locations in 18 different countries, Samtec’s global presence enables its unmatched customer service. For more information, please visit http://www.samtec.com.

Samtec, Inc.
P.O. Box 1147
New Albany, IN 47151-1147
USA
Phone: 1-800-SAMTEC-9 (800-726-8329)
http://www.samtec.com Reported by PRWeb 1 day ago.

Crash causing heavy backups on NB Aurora

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A crash near Green Lake on state Route 99 caused long delays Monday afternoon on the northbound side of the highway. Reported by SeattlePI.com 1 day ago.

New North Palm Beach Community Now Open

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Hampton Cove features 32 luxury townhomes priced from the low $400s; quick move-in homes available soon.

North Palm Beach, FL (PRWEB) July 25, 2017

K. Hovnanian® Homes has recently opened Hampton Cove, a Condominium, its newest luxury townhome condominium community in North Palm Beach. Nestled between sparkling waterways and exquisite beaches, Hampton Cove offers 32 two-story townhomes condominiums with three bedrooms, two-and-a-half bathrooms and two-car garages. Those interested should ask about quick move-in homes.

Low maintenance living at its best, residents at Hampton Cove will come home to elegant exteriors and lush landscaping that enhances curb appeal. The community will also feature a pool, cabana and gated entry.

Choose from two spacious home designs (the Aurora and Bonaire) that feature up to 2,414 sq. ft. of living space (per base plan). Additional features include two covered balconies and a lanai, two secondary bedrooms (at least 12’ x 12’ and larger), designer kitchens, open living areas and exquisite owners’ suites.

Located in picturesque Palm Beach County, K. Hovnanian’s® Hampton Cove is just six miles from the renowned golf resort in the Palm Beach Gardens area that is home to numerous public and private courses. White, sandy beaches are just 4 miles away at Juno Beach Park where miles of serene coastline await you.

For shopping and dining enthusiasts, the options in and around Palm Beach Gardens are endless. Popular venues include The Gardens Mall, Harbourside Place, Downtown at the Gardens and Legacy Place, with opportunities for waterfront dining available at every turn. Palm Beach State College is also within 3 miles. Hampton Cove is in close proximity to both the state-of-the-art Jupiter Medical Center and St. Mary’s Medical Center in West Palm Beach.

K. Hovnanian® Homes’ Hampton Cove is located at 1932 Juno Landing Lane, North Palm Beach, Florida 33408. Base pricing starts in the low $400s, which is subject to change. To learn more about Hampton Cove, visit khov.com/HamptonCove or call 561-571-8730.

ABOUT HOVNANIAN ENTERPRISES®, INC.
Hovnanian Enterprises, Inc., founded in 1959 by Kevork S. Hovnanian, is headquartered in Red Bank, New Jersey. The Company is one of the nation’s largest homebuilders with operations in Arizona, California, Delaware, Florida, Georgia, Illinois, Maryland, New Jersey, Ohio, Pennsylvania, South Carolina, Texas, Virginia, Washington, D.C. and West Virginia. The Company’s homes are marketed and sold under the trade name K. Hovnanian® Homes, Brighton Homes® and Parkwood Builders. As the developer of K. Hovnanian’s® Four Seasons communities, the Company is also one of the nation’s largest builders of active lifestyle communities.

Additional information on Hovnanian Enterprises, Inc., including a summary investment profile and the Company’s 2016 annual report, can be accessed through the “Investor Relations” section of the Hovnanian Enterprises’ website at khov.com. To be added to Hovnanian’s investor e-mail list, please send an e-mail to IR(at)khov(dot)com or sign up at khov.com.

Pricing, availability and eligibility are subject to change without notice. We are pledged to the letter and spirit of U.S. policy for the achievement of equal housing opportunity throughout the nation. We encourage and support an affirmative advertising and marketing program in which there are no barriers to obtaining housing because of race, color, religion, sex, handicap, familial status, or national origin. Reported by PRWeb 20 hours ago.

Homeless camps emerging off East Colfax have stalled deals for redevelopment of Aurora arts district

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Over the last several months, a group of homeless people have been living in the parking lot of the nonprofits Aurora Warms the Night, and their daily activities are hurting redevelopment efforts. Reported by Denver Post 8 hours ago.

5 places in Aurora for visual artists to get creative at any age, for next to nothing

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Art culture in Aurora is deep-rooted and growing quickly. For decades, art studios and creative spaces have successfully run free and almost free classes and services for visual artists of any age and talent level. Reported by Denver Post 6 hours ago.

Bogus pot deal, involving broccoli, and gunfire at Aurora mall gets man 16 years in prison

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An Aurora man involved in gunfire at a local mall over a bogus marijuana deal, which involved broccoli instead of weed, has been sentenced to prison. Reported by Denver Post 54 minutes ago.

VIDEO: Incredible footage of the Northern Lights as seen from the...

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VIDEO: Incredible footage of the Northern Lights as seen from the... Looking up at the sky and seeing the Northern Lights is an ambition many people hold.But one lucky NASA astronaut recently had the enviable opportunity to witness the spectacular phenomenon from above.And he didn't waste it.Jack Fischer was able to capture the extraordinary sight of the Aurora Borealis while on the International Space Station on Sunday.Read more: Staffordshire daughter spots dead mum watering front garden on Google StreetviewNow he's has shared the incredible time-lapse footage,... Reported by The Sentinel Stoke 3 hours ago.

What Happens to Canadian Marijuana Stocks if Legalization Is Pushed to 2019?

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Here's what investors need to know if the legalization date is delayed further, and how cannabis stocks like Aurora Cannabis Inc. (TSX:ACB) may respond. Reported by Motley Fool 4 hours ago.

CU Cancer Center Study May Explain Failure of Retinoic Acid Trials Against Breast Cancer

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Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

AURORA, Colo. (PRWEB) July 26, 2017

Estrogen-positive breast cancers are often treated with anti-estrogen therapies. But about half of these cancers contain a subpopulation of cells marked by the protein cytokeratin 5 (CK5), which resists treatment — and breast cancers with higher CK5 expression have poorer prognosis. These cells, which have characteristics of stem cells, often survive treatment to drive or even restart cancer growth. Previous work has shown that retinoic acid, a chemical that results from the body’s natural breakdown of vitamin A, should act against these CK5+ cells, but clinical trials of retinoids against breast cancer have been largely unsuccessful.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance. The study implies that perhaps if retinoic acid were used earlier in the course of treatment, resistance may be lower and this promising but unproven strategy may show more success.

The complex finding takes place in the context of the hormones estrogen and progesterone. Previous work in the lab of CU Cancer Center investigator, Carol Sartorius, PhD, and others shows that progesterone aids the expansion of CK5+ cells. This work also shows that retinoids block the ability of progesterone to increase CK5+ cell numbers. The answer seems simple: Treatment with retinoids should block the progesterone-aided expansion of this dangerous subpopulation of CK5+ cells. It works in cell studies and in mouse studies, but so far has proved frustratingly ineffective in human patients.

However, along with this seemingly linear storyline in which retinoids block progesterone’s promotion of CK5+ cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5+ cells – it is as if these therapies remove the roadblock of estrogen-dependent cells, leaving CK5+ cells to proliferate. In other words, unfortunately, anti-estrogen therapies may kill estrogen-dependent cells but at the expense of spurring the growth of CK5+ cells.

In the current paper, first author Lynsey Fettig, doctoral candidate in the University of Colorado Denver Cancer Biology Program and the Sartorius lab, first wanted to confirm that CK5 was not only marking therapy-resistant breast cancer cells but was, in fact, contributing to this resistance.

“When we used shRNA to knock down CK5, we saw no growth of these cells in response to progesterone, indicating that CK5 is in fact playing a role in the ability of progesterone to induce stem-like characteristics in these cells,” Fettig says, also citing a handful of additional confirmatory experiments. Then, “When we added progesterone, we could actually watch them turn on CK5.”

“From there, we started diving into the retinoic acid side of things,” she says.

Often, progesterone receptors sit next to genes, recruiting partners that help pull open DNA so that genes can be read. This is how progesterone boosts CK5+ cells – like tiny gatekeepers, progesterone receptors and their cofactors sit in front of the gene CK5, opening the doors of DNA to be read at this point. Retinoic acid receptors are one of these cofactors, recruiting additional proteins to open DNA. When retinoic acid is added however, these gatekeepers, including retinoic acid receptors, are called away leaving progesterone receptors without assistance in pulling open the heavy doors of DNA and causing shutdown of CK5 expression.

“Adding retinoids calls away retinoic acid receptors, which are then unable to aid transcription of the gene,” Fettig says.

Importantly, knowing the mechanism by which retinoids reduce CK5 activation now leads the team to a hypothesis that could stop this activation. When the team used the retinoid fenretinide along with anti-estrogen therapy in mouse models of breast cancer, they did not see the expansion of CK5+ cells previously seen with anti-estrogen therapy alone.

“What has been missing in clinical trials may just be the timing of the treatments,” Fettig says.

Previous trials of retinoids against breast cancer have been conducted only after anti-estrogen treatments, at which point, “we were already getting expansion of cancer stem cells – treating with a retinoid after that was already too late,” Fettig says. In support of this, fenretinide has been shown to be effective at preventing breast cancer recurrence in premenopausal women.

The current paper shows that treating with retinoids simultaneously with anti-estrogen therapies may pull cofactors for progesterone receptors away from their posts, disallowing their ability to open DNA at the point of CK5 and keeping the growth of dangerous CK5+ cells in check. Reported by PRWeb 3 hours ago.

Astronaut relates 'awesome' aurora to Mexican food

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Astronaut Jack Fischer tweeted this time-lapsed video from the ISS, adding that this view of an aurora looks like a "burrito of awesomeness smothered in green awesome sauce."

 
 
 
 
 
 
  Reported by USATODAY.com 2 hours ago.

Opioid crisis a driver in higher psychiatric admissions at Aurora Health Care

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The opioid crisis is one driver of a large increase in inpatient admissions at Aurora Health Care’s psychiatric hospital over the past three years. Reported by bizjournals 21 hours ago.

Fake Marijuana Deal Involving Broccoli and Gunfire Gets Man 16 Years in Prison

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Fake Marijuana Deal Involving Broccoli and Gunfire Gets Man 16 Years in Prison An Aurora man is going to jail after a bogus drug deal that involved broccoli in place of marijuana led to a shooting at a local mall.

A jury found Sababu Colbert-Evans, 26, guilty of attempted first degree murder in … Reported by Epoch Times 19 hours ago.

NASA astronaut captures aurora space spectacle

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NASA astronaut Jack Fischer has shared stunning time-lapse images of the aurora borealis he captured from the International Space Station on June 26 and shared on Sunday. — Reuters Reported by Bangkok Post 4 hours ago.

Astronics Corporation Announces Second Quarter 2017 Financial Results Conference Call and Webcast

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Astronics Corporation Announces Second Quarter 2017 Financial Results Conference Call and Webcast EAST AURORA, N.Y.--(BUSINESS WIRE)--Astronics Corporation Announces Second Quarter 2017 Financial Results Conference Call and Webcast Reported by Business Wire 3 hours ago.

10 Things You Never Knew About... Arcade Fire

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10 Things You Never Knew About... Arcade Fire Looking back on a decade of powerful music...

*Arcade Fire* have graced the indie landscape for over a decade with their conceptual albums and political statements.

Following 2013’s ‘Reflector’ it has been quiet from the Canadian outfit, though this summer they will bring their immense live act around a handful of events, including the Isle Of Wight Festival.

With new album ‘Everything Now’ set to drop tomorrow (July 28th) here are 10 things you might not have known about the Montreal band.

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*The band name* was rumoured to stem from a fire in an arcade. When asked about it, frontman Win Butler replied: "It's not a rumour, it's based on a story that someone told me. It's not an actual event, but one that I took to be real. I would say that it's probably something that the kid made up, but at the time I believed him."

*For the recording of ‘Neon Bible’*, Arcade Fire bought a church in the Quebec area. Turning it into a recording space, the church was also the studio for 2010 album, ‘The Suburbs’. The band had to leave after the roof started collapsing, and a real estate listing came up for the building in 2013 with the description: “Charming church which housed a small concert hall, followed by a recording studio also offering accommodation. Its architecture makes it a perfect location for an artist's studio, a place of worship, a cultural, community or other organization. Offer here a unique setting to your project!”

*Arcade Fire and David Bowie* were quite a music love affair. The group have stated that “David Bowie was one of the band’s earliest supporters and champions.” From early on Bowie would come to their gigs, and he even bought all the copies of ‘Funeral’ at Tower Records in Houston. The artist stated that: “There’s a certain uninhibited passion in the Arcade Fire’s huge, dense recording sound. I bought a huge stack of the ‘Funeral’ CD last September and gave them to all my friends. I made so many converts.”

*David Bowie and Arcade Fire* also collaborated on a joined Live EP to raise money to support the victims of Hurricane Katrina in New Orleans. Further on, Bowie’s vocals are featured on the group’s most recent studio release, ‘Reflector’.

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*Arcade Fire’s breakthrough record ‘Funeral’* got its name from the trio of deaths that haunted the writing and recording of the masterpiece. Regine Chassagne’s grandmother, Win and William Butler’s grandfather and Richard Reed Parry’s aunt all set colour to ‘Funeral’s music and title.

*Arcade Fire* have never been subtle about their political stands and their backing of President Obama even saw them play alongside Jay-Z at the Obama Staff Ball in Washington. The group played songs from ‘Funeral’ and ‘Neon Bible’ along with a cover of Springsteen’s ‘Born in the U.S.A.’.

*The Canadians were less pleased with Trump.* The band released new single ‘I Give You Power’ on January 19th to coincide with Donald Trump’s inauguration. The song featured guest vocals from singer and civil rights activist, Mavis Staples. “It’s the eve of the inauguration and I think it’s easy to get sucked into sitting on the couch and checking your news feed and watching things on CNN, and we’re just musicians and the only thing we really have to offer is our music,” Win Butler stated in an interview with Zane Lowe.

*Due to Regine Chassagne’s Haitian heritage*, Arcade Fire has, throughout their career, raised awareness and supported Haiti. On December 26th, 2006, the band was supposed to release ‘Intervention’ on iTunes to support the Partners In Health charity. However, they accidentally uploaded the wrong track leading to ‘Black Wave / Bad Vibrations’ leaking two days too early. As Butler stated. “I guess it is sort of charming that we can send the wrong song to the whole world with a click of a mouse… oh well.”

*Across the band’s seven members*, Arcade Fire can play over 16 instruments, including violin, viola, cello, double bass, xylophone, Glockenspiel, French horn, harp, mandolin, and hurdy-gurdy. They also bring most of these with them on tour.

*William Butler and Owen Pallett *spent over a year collaborating on the soundtrack for Spike Jonze’s Her. “Working on something where you had to defer to the director and see it through his eyes was a great musical challenge that you could apply to everything else,” Butler said about the experience that ultimately gained him an Oscar nomination for Best Original Score.

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'Everything Now' will be released on July 28th.

Words: *Aurora Henni Krogh*

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