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Aurora HDR 2017 first look: Macphun's flashy editor turbocharges your photos

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Aurora HDR 2017, an update to Macphun’s nearly year-old HDR app, is dedicated to making your photos sizzle with light and color. Part of that is the influence of photographer Trey Ratcliff, who partnered with the software company to develop the app, including his signature line of presets within the software.

Another part is the realization that photos—particularly landscapes and cityscapes, nature, and other scenic compositions—often fail to measure up to the scene most people remember seeing in real time. HDR can work toward realigning memory with reality, especially if the photographer has the foresight to bracket multiple shots with different exposures with the intention of combining them later. Though Aurora can also work with single shots.

To read this article in full or to leave a comment, please click here Reported by Macworld 19 hours ago.

NTS Expands Testing Services in Colorado

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NTS Now Offers Environmental and Dynamics Testing including Temperature, Altitude, Vibration, Shock, and many other Capabilities

Longmont, Colorado (PRWEB) September 14, 2016

National Technical Systems, Inc. (“NTS”), the leading independent provider of environmental simulation testing, inspection, and certification solutions in the United States, has recently acquired the test equipment assets for an additional facility in Longmont, Colorado. Financial details of the acquisition were not disclosed.

The new facility will be known as NTS Longmont West and is located eight miles from the existing NTS Longmont EMC laboratory (formerly EMC Integrity). Combined, these two facilities uniquely fulfill the regions need for a single resource for both environmental/dynamics and EMC/EMI testing.

The NTS Longmont West capabilities include independent and combined environments covering testing categories such as thermal cycling and shock, humidity, altitude, overpressure, blowing rain, vibration, shock, HALT, acceleration, and package testing. Combined temperature and humidity capabilities include walk-in and drive-in, man rated chambers allowing the evaluation of larger equipment and systems. Vibration capabilities include high acceleration and displacement electrodynamic as well as servo hydraulic shakers. Also available are a variant of package testing systems including drop shock towers and sled (also capable of evaluating components for aircraft), bounce, transportation vibration, and impact.

“We are pleased and excited to be able to offer our Colorado region clients these new services,” stated Vicki Panhuise, CEO of NTS. “This full-service environmental lab perfectly complements the EMC expertise in our existing Longmont facility.”

A ribbon cutting and open house is scheduled for September 30, 2016. Click here for Open House details.

NTS is a portfolio company of Los Angeles-based Aurora Capital Group.

About National Technical Systems
National Technical Systems, Inc. (NTS) is a global independent provider of environmental simulation testing, inspection, and certification services, serving a broad range of industries, including the civil aviation, space, defense, nuclear, telecommunications, industrial, electronics, medical, and automotive end markets. During its more than 50 years in business, NTS has built the broadest geographic presence and sole national footprint in the United States, an unparalleled breadth of capabilities, and has fostered continuous innovation, making NTS a unique one-stop resource to meet its clients’ demanding and evolving requirements. Operating through a network of 28 technologically advanced testing laboratories across the United States, this geographically diverse footprint puts NTS facilities in close proximity to its more than 4,000 clients, allowing NTS to serve the nation’s most innovative companies with industry-leading accessibility and responsiveness. NTS’ offering spans more than 70 distinct environmental simulation and materials testing categories, including climatic, structural, dynamics, fluid flow, EMI/EMC, lightning, product safety, acoustics, failure analysis, chemical, and other industry-specific tests, allowing it to handle its clients’ most demanding needs. Additionally, the company is accredited by numerous national and international organizations, which allows NTS to have its test data nearly universally accepted worldwide. NTS operates its inspection division under the Unitek brand, providing a wide range of supply chain management services. NTS’ certification division, which operates under the NQA brand, is one of the largest and most respected global ISO registrars, with active certifications in more than 75 countries. For additional information about NTS, visit our website at http://www.nts.com or call 800-270-2516.

# # # # Reported by PRWeb 17 hours ago.

Solon Police Conducting Sobriety Checkpoint Friday

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Solon Police Conducting Sobriety Checkpoint Friday Patch Solon, OH -- Officers will be looking for impaired drivers in the vicinity of Aurora Road on Sept. 16. Reported by Patch 11 hours ago.

CU School of Medicine exec to lead new Texas cancer-research center

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The head of the Division of Medical Oncology at the University of Colorado School of Medicine in Aurora is leaving to lead a new cancer-research center at the University of Texas. UT's Dell Medical School has named Dr. S. Gail Eckhardt to head its new Livestrong Cancer Institutes at the Austin-based medical school as inaugural director and an associate dean. It took a $6 million grant from the Cancer Prevention and Research Institute of Texas to help attract Dr. Eckhardt. Before moving to Colorado,… Reported by bizjournals 11 hours ago.

Seven-year Study Pays Off with ‘Most Detailed’ Picture of Head and Neck Cancer Stem Cells to Date

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University of Colorado Cancer Center study shows how 'key genetic alterations' drive head and neck cancer growth

AURORA, Colo (PRWEB) September 14, 2016

Cancer stem cells resist therapy and are a major cause of relapse, long after the bulk of a tumor has been killed. A University of Colorado Cancer Center study published in the Journal of the National Cancer Institute provides the most comprehensive picture to date of head and neck cancer stem cells, identifying genetic pathways that cancer stem cells hijack to promote tumor growth and visualizing the process of “asymmetric division” that allows a stem cell to create tumor tissue cells while retaining its own stem-like profile. The study is the result of seven years of research and innovation, including the development of novel techniques that allowed researchers to identify, harvest, and grow these elusive stem cells into populations large enough to study. This major body of work provides specific targets for the development of new cancer therapeutics.

“We wanted to determine the relationships between key genetic alterations and how head and neck cancer stem cells harness those alterations to drive initiation and growth,” says CU Cancer Center investigator Antonio Jimeno, MD, PhD, the Daniel and Janet Mordecai endowed professor for cancer stem cell research, director of the University of Colorado School of Medicine’s Head and Neck Cancer Clinical Research Program, and the paper’s senior author. The current project was performed in collaboration with the Gates Center for Regenerative Medicine of which Dr. Jimeno is a faculty member. Jimeno started his work with cancer stem cells as a post-doc at Johns Hopkins University, but as he explains, “I focused on head and neck cancer stem cells because there has been an increase in head and neck cancer incidence of about fifty percent over the past ten years in the U.S. and we need to better understand what is at the root of this disease.”
Previously, a major challenge in characterizing cancer stem cells has been gathering a cell population large enough to study.

“There is a lot of ‘noise’ in cells and you need a lot of them because with only a few cells, it’s impossible to tell which of these genetic differences are meaningful features of cancer stem cells and which are just genetic noise,” says first author Stephen Keysar, PhD, research assistant professor in the Jimeno lab.

To solve this problem, the group first gathered tumor samples from a larger number of head and neck cancer patients – 10 patients in all – more than in any previous study. These samples represented both tumors associated with alcohol and tobacco use and tumors caused by the human papilloma virus (HPV).

“It is important to always remember that we were able to make a difference thanks to the generosity of our patients, who enabled us to work with representative cancer models,” Jimeno says.

These tumors were then grown in mice. Subsequently, the group undertook the painstaking process of isolating enough cells for genetic studies and one-by-one transplanting these patient-derived tumor samples onto new mice to study how cancer stem cells initiate tumor growth.

“Sometimes it took a year just to get enough cells to study,” Keysar says.

“Antonio is a great example of perseverance,” says Dennis Roop, PhD, director of the Gates Center and also an investigator at the CU Cancer Center and the individual whom Jimeno credits with “much of the philosophy behind this work.” “Antonio was submitting all these grants, and the reviewers were saying, ‘There’s no way you can do this; there’s no way you’ll get enough cells to characterize.’ He simply found ways to prove them wrong.”

This included leveraging private research funding, primarily from the Gates Center for Regenerative Medicine, the Daniel and Janet Mordecai Foundation and the Peter and Rhondda Grant Fund.

“Private funding allowed Antonio to do the groundwork and develop the techniques that eventually made his proposals to the NIH so compelling that he was able to get support. In the case of those of us who are driven to do what we do, you just find a way to get these things accomplished. This is a great example of how bridge funding from the private sector can move research forward,” Roop says.

Here is what the group found:

First, head and neck cancer stem cells are, in fact, distinct from the rapidly dividing cells that form the bulk of tumors, and there is little difference between cancer stem cells in HPV- and HPV+ cancers. Both are marked by CD44 expression and aldehyde activity, and both use the key pathway PI3K to drive their survival, growth and resistance to anti-cancer therapies. The group found that the PI3K pathway, which is the most common alteration in head and neck cancer, then deploys SOX2, a transcription factor, to activate programs that modulate ‘stemness’ within the cell’s nucleus. For example, SOX2 was found to control aldehyde activity, which is a common cancer stem cell marker and a well-known driver of cancer stem-cell-mediated tumor growth.

“In normal cells, PI3K is used as a sensor for energy,” Jimeno explains. “For a cancer cell to act cancerous, it needs metabolic flexibility – it needs to be able to over-use energy – and so this ‘energy sensor’ is a pathway it wants to hijack. After chemo, PI3K helps the cell shut down and weather the storm. Then when the chemo is gone, PI3K helps cancer stem cells start back up again.”

Chemotherapies kill rapidly-dividing cells. PI3K shuts down a cancer stem cell’s metabolism, placing the cell in a dormant state. This gives cancer stem cells the ability to evade the trap of chemotherapy.

So what happens when you remove this ability? When the group eliminated SOX2 in mouse models of head and neck cancer, tumors became sensitive to therapies that previously had failed. But when the group amplified SOX2, tumors became even more resistant.

“This molecular thread from PI3K to SOX2 to aldehyde was responsible for all the features that define cancer stem cells,” Keysar says. Further, “Since SOX2-expressing cells fully behave like cancer stem cells, we now have a new laboratory tool to study cancer stem cell biology and therapeutics.”

The work also allowed the group to witness an event of the stem cell cycle that had, at best, been only partially characterized in head and neck cancer.

“It was like the snow leopard of the Himalayas,” Jimeno says. “We knew it existed because of the tracks, but no one had taken a picture of it – that is, until someone patiently perched on a frozen ridge for two years with a camera. We did just that.”

The event Jimeno refers to is “asymmetric division” of cancer stem cells. When a normal cell divides, it creates two identical copies of itself. However, if stem cells divided symmetrically, it would result in two stem cells but no differentiated cells, or two differentiated cells with the loss of the original stem cell. In either case, symmetrically dividing stem cells would not be able to promote tumor growth while also retaining their stemness.

The group was able to document that when cancer stem cells divide, “they don’t divide into two of the same,” Jimeno says. “One cell retains a stem profile, and the other goes a step beyond into differentiation.”

Overall, this seven-year line of inquiry offered three major advances: it characterized head and neck cancer stem cells; it documented asymmetric division in head and neck cancer stem cells; and it identified genetic mechanisms that allow these cancer stem cells to grow and resist therapy. Importantly, identifying these genetic mechanisms of resistance may also help researchers and doctors overcome it.

“SOX2 and aldehyde inhibitors are now under exploration, and we’ve also done trials of early PI3K inhibitors here at CU Cancer Center,” Jimeno says.

“This has been an excellent example of team science,” Roop says. “You have Antonio – a brilliant young clinician-scientist – leading a group that includes basic scientists, pathologists, bio-informaticians and statisticians, and their expertise can combine to attack a problem in a way that no individual would be able to do on their own. This work will provide the basis for the development of new therapeutic strategies.” Reported by PRWeb 9 hours ago.

Aurora Drug Dealer Found Guilty of Large Scale Drug Operation: Prosecutors

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Aurora Drug Dealer Found Guilty of Large Scale Drug Operation: Prosecutors Patch Montgomery, IL -- Meth, cocaine and marijuana found in his home was worth as much as $1.3 million. Reported by Patch 18 hours ago.

Aurora Theater Shooting Victims Not Stuck With Legal Fees

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A group of Aurora theater shooting victims will not be stuck with paying nearly $700,000 in legal fees of Cinemark after the cinema dropped its request in state court Tuesday. Reported by Newsmax 18 hours ago.

See Alaska's captivating Northern Lights on this Fairbanks tour

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If you like light shows, you’ll love this tour to see Alaska’s aurora borealis, the dancing lights that draw visitors and residents alike into the cold night air every winter.

The six-night Fairbanks, Alaska, tour will focus on the northern lights, which are particularly easy to spot in Fairbanks... Reported by L.A. Times 16 hours ago.

Milwaukee Business Journal reveals 44 Best Places to Work winners for 2016

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The Milwaukee Bucks, Marquette University, Mortenson Construction and Aurora Health Care are among the winners of the Milwaukee Business Journal's 2016 Best Places to Work awards. Other winners include Quarles & Brady LLP, Milwaukee; GMR Marketing, New Berlin; Eppstein Uhen Architects Inc., Milwaukee; and C.G. Schmidt, Milwaukee. In all, 44 southeastern Wisconsin companies are being honored for having the best culture and leadership and where employees feel the most engaged by their jobs and management. Nearly… Reported by bizjournals 17 hours ago.

Cinemark drops $700,000 legal bill issued to Aurora victims

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Cinemark, having successfully fought a lawsuit brought on by victims of the 2012 Colorado theater shooting, will not pursue incurred legal costs. Reported by Christian Science Monitor 14 hours ago.

Cinemark drops bid to recoup $700,000 in litigation costs from Aurora victims

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Cinemark, having successfully fought a lawsuit brought on by victims of the 2012 Colorado theater shooting, will not pursue incurred legal costs. Reported by Christian Science Monitor 16 hours ago.

Apple's Sunnyvale Car Team Includes a Dozen Magna Engineers

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In a piece on car company Magna International, Bloomberg has shared a tidbit about Apple's car development plans, suggesting there are approximately a dozen engineers from Magna working with Apple's car team in Sunnyvale.

Magna employees are said to be helping develop Apple's electric vehicle, reigniting rumors that Apple is working with a third-party to manufacture its vehicle rather than taking on vehicle development costs itself.
A completely new vehicle can cost several billion dollars, so leaning on the expertise of an industry veteran is a way of minimizing those costs. Apple has been quick to understand that: about a dozen Magna engineers have been working with the iPhone-maker's team in Sunnyvale to develop a vehicle, according to a person familiar with the arrangement.

This isn't the first time we've heard rumors of some kind of partnership between Apple and Magna. In April, a German news site suggested Apple had a secret car lab in Germany and was planning to have subsidiary Magna Steyr manufacture its cars, and Apple executives also visited Magna Steyr in Austria in February of 2015. Apple also reportedly held talks with Daimler and BMW, but no deal was able to be established due to questions over who would lead the project and who would have ownership over data.

Magna executives and Apple both declined to comment on rumors of a partnership, but in a separate interview on plans to build a new car plant, Magna CEO Donald Walker spoke on partnerships like the one the company has established with BMW. Magna will be producing BMW's 5-Series and is said to be "positioning itself for the prospect that technology companies will eventually join its roster of customers."

"You could easily have enough business outsourced from the existing carmakers to fill up other contract assembly plants, or you could have new entrants that come in and say 'I really want to have something but do I really want to manufacture vehicles?,"' Magna Chief Executive Officer Donald Walker said in an interview at the company's headquarters in Aurora, Ontario.

While Apple has hundreds of employees working on its car project, the company's plans seem to be in flux. Following Bob Mansfield's takeover of the car initiative earlier this year, Apple is said to have laid off dozens of employees as part of a "reboot" that will see focus shifting towards the development of an autonomous vehicle system. Based on these recent rumors, it is no longer clear if a physical Apple-branded car will actually materialize or if the project will result in something more software oriented.
Discuss this article in our forums Reported by MacRumours.com 15 hours ago.

Aurora HDR crafts a digital polarizing filter in a major software update

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Aurora HDR crafts a digital polarizing filter in a major software update In a 20+ feature upgrade, Aurora HDR has added a digital polarizing filter to its software. The latest update also offers faster processing, enhanced tone mapping, easy selection tools, and more. Reported by Digital Trends 13 hours ago.

Naperville, Aurora Students Named National Merit Semifinalists

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Naperville, Aurora Students Named National Merit Semifinalists Patch Naperville, IL -- National Merit Scholarship winners will be announced April through July of 2017. Reported by Patch 11 hours ago.

Mayor does about-face, shelves North Precinct police station plan

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Seattle Mayor Ed Murray said the city will re-think its $149 million plan to build a new police station on Aurora Avenue North. Reported by Seattle Times 6 hours ago.

Fisher-Price looking to fill 100 seasonal positions in East Aurora

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Fisher-Price is seeking to fill more than 100 seasonal positions beginning in October and November and running through the holiday season. The East Aurora-based company – a subsidiary of California-based Mattel Inc. (NASDAQ: MAT) – needs employees for its Mattel Consumer Services Center in East Aurora, which provides product and technical support to the entirety of North America on key Mattel brands such as Hot Wheels, Barbie, Fisher-Price, Thomas & Friends and MEGA, according to a Fisher-Price… Reported by bizjournals 16 hours ago.

Lone Fugitive Wanted in Operation Tri-Lambs Investigation Arrested in Warrenville

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Lone Fugitive Wanted in Operation Tri-Lambs Investigation Arrested in Warrenville Patch Glen Ellyn, IL -- Sixteen Aurora gang members face a total of 96 felony charges following the three-year investigation. Reported by Patch 13 hours ago.

Business site selection consultants get bird's eye view of metro Denver

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From three helicopters, nine site selection pros scouting locations for dozens of companies looked out over Denver this week. They flew over the University of Colorado Anschutz Medical Campus in Aurora and then came around south to see the Charles Schwab Corp. campus in Lone Tree for a good look at how the city lays out. There was no hard sell, said Tom Clark, CEO of the Metro Denver Economic Development Corp. and executive vice president of the Denver Metro Chamber of Commerce. “We were letting… Reported by bizjournals 12 hours ago.

Froedtert, Children's Hospital disappointed at exclusion from Humana HMO

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Representatives of Froedtert & the Medical College of Wisconsin Health and Children’s Hospital of Wisconsin said they were disappointed they never received an invitation to join Humana’s new Wisconsin HMO. The HMO that Humana Inc. announced Tuesday includes the state’s two largest health care systems: Milwaukee-based Aurora Health Care and Glendale-based Ascension Wisconsin. Also in the new HMO’s network are ProHealth Care of Pewaukee and Bellin Health of Green Bay. “We are deeply disappointed… Reported by bizjournals 11 hours ago.

One person killed in high-speed Aurora crash

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A passenger in a speeding car was killed late Friday night after the car's driver slammed into a median on Interstate 225 and the car rolled several times. Reported by Denver Post 15 hours ago.
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